A promising discovery for a definitive treatment for both types of diabetes

 In a step that brings the world closer to the possibility of developing an effective treatment for type 1 and type 2 diabetes, a study conducted by researchers in Germany discovered that promising results are achieved in that direction when disabling one of the receptors that inhibits insulin secretion in the body, if it turns out that this leads to activation and an increase in the level of insulin secretion. sensitivity of the insulin signaling pathway in pancreatic beta cells; This protects these cells and allows them to regenerate and begin to secrete insulin.

The study was conducted by a team of researchers under the supervision of the German National Center for Diabetes Research, and was published in the specialized scientific journal Nature, whose results were described as “a milestone in the field of diabetes research.”

In laboratory experiments with mice, the researchers sought to explore the consequences of inactivating this inhibitory receptor (IGF1R) by eliminating it in pancreatic beta cells and by inactivating it with monoclonal antibodies.

In their final report, the researchers said that the results were encouraging, as they noted a significant increase in insulin signaling along with the growth of functional beta cells in the pancreas.

Insulin blocking receptor

Because these results demonstrate that targeting this inhibitory insulin receptor could open up unprecedented avenues for treating beta cell loss and dysfunction, the researchers hope that their discovery will contribute to the development of a diabetes treatment based on inhibiting IGF1R cells, while at the same time targeting pancreatic beta cells. With therapeutic molecules that correct the way they work and reactivate their ability to naturally secrete the hormone insulin.

It is noteworthy that diabetes mellitus is a highly complex disease that arises due to the loss or disruption of insulin-producing beta cells in the "islets of Langerhans", which are small groups of pancreatic cells whose function is to regulate and control blood sugar levels.

Complications of diabetes include chronic hyperglycemia and systemic metabolic failure. In the long term, the disease may lead to damage to some organs of the body, and may lead to early death if it is not controlled.

The results of previous research studies indicate that intensive insulin therapy helps improve blood sugar control and thus relieve symptoms of diabetes, but it also leads to unwanted weight gain in addition to a group of more serious side effects such as an increased risk of a significant decrease in blood sugar. Blood sugar leading to diabetic coma.

So far, there is no drug or gene therapy that can stop a diabetic patient's dependence on insulin-replacement pharmaceuticals.

about a century ago; In his speech before the Nobel Prize Committee, the discoverer of insulin, Frederick Banting, emphasized that insulin is not a cure for diabetes, but rather a symptom relief only. So; What German researchers have discovered may be a radical cure for the incurable disease that affects about 500 million people around the world.

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